Ayahuasca contains DMT and MAO inhibitors (harmala alkaloids). These compounds can cause serious interactions and health risks.
Absolute Contraindications (Do Not Use)
- Psychiatric Conditions
Schizophrenia
Bipolar disorder (especially Type I)
Psychotic disorders
Severe dissociative disorders
History of psychosis in yourself or first-degree relatives
Risk: May trigger prolonged psychosis or manic episodes. - Use of Serotonergic Medications
Do not combine with:
SSRIs
SNRIs
MAO inhibitors
Tricyclic antidepressants
Triptans (for migraines)
Stimulants (e.g., amphetamines)
MDMA, GHB, cocaïne, heroïne etc….
St. John’s Wort
Risk: Serotonin syndrome (high fever, agitation, muscle rigidity, high blood pressure, heart problems; can be life-threatening).
Note: Never abruptly stop prescribed psychiatric medications without medical supervision. - Cardiovascular Disease
Uncontrolled high blood pressure
Heart disease
Arrhythmias
History of stroke
Ayahuasca can raise blood pressure and heart rate. - Neurological Conditions
Epilepsy or seizure disorders
History of seizures or significant brain injury - Pregnancy and Breastfeeding
Use is not recommended due to potential risks to fetus or infant.
Relative Contraindications (Require Medical Evaluation)
- Severe anxiety or panic disorders
- PTSD
- Personality disorders
- Substance use disorders
- Diabetes (vomiting may destabilize glucose)
- Liver disease (harmala alkaloids are metabolized in the liver)
- Psychological Risks
- Even healthy individuals may experience:
- Panic reactions
- Flashbacks
- Depersonalization/derealization
- Difficulty integrating the experience
- Rarely, persistent psychosis
Drug and Food Interactions (MAOI Effects)
Avoid:
- Aged cheeses
- Cured meats
- Fermented soy products
- Excess caffeine
- Alcohol
- Although traditional ayahuasca MAOIs are reversible and dietary restrictions are less strict than pharmaceutical MAOIs, caution is still recommended.
Important Notes
There is no universal medical screening for ayahuasca retreats; self-reports may miss risk factors.
Medical consultation is recommended, especially for psychiatric or cardiovascular concerns.